METHACYCLINE HYDROCHLORIDE
Methacycline Hydrochloride
CAS: 3963-45-9;3963-95-9
Molecular Formula: C19H24O2
METHACYCLINE HYDROCHLORIDE - Names and Identifiers
METHACYCLINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C19H24O2 |
| Molar Mass | 284.39 |
| Boling Point | 813.8°C at 760 mmHg |
| Flash Point | 445.9°C |
| Vapor Presure | 5.4E-28mmHg at 25°C |
| Storage Condition | -20℃ |
| Use | This product is for scientific research only and shall not be used for other purposes. |
METHACYCLINE HYDROCHLORIDE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
METHACYCLINE HYDROCHLORIDE - Standard
Authoritative Data Verified Data
This product is 6-methylene-4-(dimethylchloride)-3,5,10,12, 12a-penta-light -1,11-dioxo-1, 4,4a,5,5a,6,11,12a-octahydro-tetrabenzamide hydrochloride. Containing not less than 87.0% of dextromethorphan (C22H22N208) on a dry basis.
Last Update：2024-01-02 23:10:35
METHACYCLINE HYDROCHLORIDE - Trait
Authoritative Data Verified Data
- This product is yellow crystalline powder; Odorless.
- This product is slightly soluble in water or methanol.
Last Update：2022-01-01 15:32:25
METHACYCLINE HYDROCHLORIDE - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product, add water to dissolve and dilute to make a solution containing about lOug per lml, and measure by UV-Vis spectrophotometry (General rule 0401), there is maximum absorption at 282nm and 241nm wavelengths and minimum absorption at 264nm and 222nm wavelengths.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1026).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:32:26
METHACYCLINE HYDROCHLORIDE - Exam
Authoritative Data Verified Data
acidity
take this product 0.lg, add water 10ml ultrasonic to dissolve, according to the law (General 0631),pH value should be 2.0~3.0.
Related substances
take this product, add O.Olmol/L hydrochloric acid solution is dissolved and diluted to make a solution containing about 0.2mg per 1 ml as a test solution; Take an appropriate amount of precision, and use O.Olmol/L hydrochloric acid solution was quantitatively diluted to prepare a solution containing about 2ug per 1 ml as a control solution. According to the chromatographic conditions under the content determination item, 2 u1 of the test solution and the control solution are accurately taken, respectively injected into the human liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 1.2 times (1.2%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 3 times (3.0%) of the main peak area of the control solution.
absorbance of impurities
take this product, add lmol/L hydrochloric acid methanol solution (1-100) to dissolve and quantitatively dilute to prepare a solution containing 10 mg per lml, UV-visible spectrophotometry (General rule 0401), measured at a wavelength of 490mn, absorbance should not exceed 0.20.
loss on drying
take 0.2~0.3g of this product, dry to constant weight at 105°C, and lose no more than 1.5% of weight (General rule 0831).
ignition residue
not more than 0.2% (General rule 0841).
Last Update：2022-01-01 15:32:27
METHACYCLINE HYDROCHLORIDE - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with octylsilane as filler; Acetate buffer [0.25mol/L ammonium acetate solution -0.1 mol/L ethylenediamine tetraacetic acid disodium solution-triethylamine (100:10:1), using glacial acetic acid to adjust pH value to 8.3]-acetonitrile (85:15) as mobile phase; the column temperature was 35°C and the detection wavelength was 280nm. Take the appropriate amount of the oxytetracycline control and the control of the drug, and use the O.Olmol/L hydrochloric acid solution was dissolved and diluted to make each containing 0. For the mixed solution of lmg, 20u1 was injected into human liquid chromatograph, and the chromatogram was recorded. The resolution between oxytetracycline peak and metaxin peak should be greater than 6.0.
assay
take the right amount of this product, precision weighing, plus O.Olmol/L hydrochloric acid solution was dissolved and quantitatively diluted to make about 0.lmg solution, as a test solution, take 20 u1 for precision measurement, inject human liquid chromatography, record the chromatogram; Take appropriate amount of the reference substance of the United States and the same method for determination. The content of C22H22N2O8 in the sample was calculated by the peak area according to the external standard method.
Last Update：2022-01-01 15:32:27
METHACYCLINE HYDROCHLORIDE - Category
Authoritative Data Verified Data
Tetracycline antibiotics.
Last Update：2022-01-01 15:32:28
METHACYCLINE HYDROCHLORIDE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:32:28
METHACYCLINE HYDROCHLORIDE - Metoprolol hydrochloride tablets
Authoritative Data Verified Data
This product contains 90.0% ~ 110.0% of the labeled amount according to the calculation of the salt of the United States (C22H22N208).
trait
This product is sugar-coated tablet or film-coated tablet, which shows yellow to Earth-yellow color after removing the coating.
identification
- after removing the coating, the product was finely ground and the fine powder was subjected to the identification tests (1) and (4) under the item of hydrochloric acid and the same results were shown.
- take this product, remove the coating, grind, take appropriate amount, add water to dissolve and dilute to make a solution containing about 10ug of metaxin per lml, filter, the filtrate was taken as the test solution, and the same result was shown according to item (2) of identification of metaxin hydrochloride.
examination
- Related substances take an appropriate amount of fine powder of this product and add O.Olmol/L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 0.2mg of mecyclin per 1 ml, filtered, and the continued filtrate was taken as the test solution, according to the method for the determination of hydrochloric acid under the item of hydrochloric acid, should comply with the provisions.
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 60 rpm, according to the law, after 45 minutes, take the appropriate amount of the solution, filter it, take 5ml of the filtrate accurately, put it in a 50ml measuring flask, dilute it with water to the scale, shake it well, measure absorbance at the wavelength of 345nm by UV-Vis spectrophotometry (General rule 0401), water was added to dissolve and quantitatively diluted to prepare a solution containing about 10ug per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, remove the coating, precision weighing, fine grinding, precision weighing to take appropriate amount (about equivalent to the United States and its ring hormone O.lg), put in a 100ml measuring flask, add O.Olmol/L hydrochloric acid solution to dissolve and dilute to the scale, shake, filter, precision take the filtrate 5ml, put 50ml flask, with 0. The Olmol/L hydrochloric acid solution was diluted to the scale, and shaken well. As a test solution, it was obtained by measuring according to the method under the item of metaxine hydrochloride.
category
same as that of metaxine hydrochloride.
specification
0.lg (based on C22H22N208)
storage
sealed and stored in a cool and dry place.
Last Update：2022-01-01 15:32:29
METHACYCLINE HYDROCHLORIDE - Ritacycline hydrochloride capsules
Authoritative Data Verified Data
This product contains 90.0% ~ 110.0% of the labeled amount according to the calculation of the salt of the United States (C22H22N208).
identification
- the contents of this product were taken and the same results were shown according to the identification tests (1) and (4) under the item of hydrochloric acid.
- take the contents of this product, add water to dissolve and dilute to prepare a solution containing about 10ug of metaxin per lml, filter, and take the continued filtrate as the test solution, according to the test of identification (2) of hydrochloric acid, the same results were shown.
examination
- the contents under the item of difference in loading amount of related substances shall be mixed evenly, and the appropriate amount shall be accurately weighed and O shall be added. Olmol/L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 0.2mg of mecyclin per 1 ml, filtered, and the continued filtrate was taken as the test solution, according to the method of hydrochloric acid under the item of the determination of hydrochloric acid, should comply with the provisions.
- weight loss on drying the contents of this product shall be dried to constant weight at 105°C, and the weight loss shall not exceed 2.0% (General rule 0831).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 60 rpm, according to the law, after 45 minutes, take the appropriate amount of the solution, filter it, take 5ml of the filtrate accurately, put it in a 50ml measuring flask, dilute it with water to the scale, shake it well, measure absorbance at the wavelength of 345nm by UV-Vis spectrophotometry (General rule 0401), water was added to dissolve and quantitatively diluted to prepare a solution containing about 10ug per 1 ml, which was determined by the same method, and the dissolution amount of each particle was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the difference of loading amount, mix evenly, weigh an appropriate amount (approximately equivalent to 0.lg of metaxin) accurately, and put it in a 100ml measuring flask, add 0.01mol/L hydrochloric acid solution to dissolve and dilute to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in 50ml measuring flask, use 0. The Olmol/L hydrochloric acid solution was diluted to the scale, and shaken well. As a test solution, it was obtained by measuring according to the method under the item of metaxine hydrochloride.
category
same as that of metaxine hydrochloride.
specification
calculated by C22H22N208 (1)0.lg (2)0.2g
storage
sealed and stored in a cool and dry place.
Last Update：2022-01-01 15:32:29
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